The memantine dosage will differ based on the use case. Memantine HCl is an antagonist of NMDAR.It is also a CYP2B6 and CYP2D6 inhibitor for recombinant CYP2B6 and CYP2D6 with IC50 of 1.12 μM and 242.4 μM, Ki of … I have just awoken at 90+ hours, and I think I'm finally pretty much back to baseline. I can't compare it to MXE, and it's been a few months since I last had ketamine but I'll do the best I can to explain. YOU WILL BE BANNED FOR ASKING OR PROVIDING DRUG OR PARAPHERNALIA SOURCES, whether illegal or legal. The one time I've combined LSD and a recreational dose of Memantine was one of the single most euphoric experiences I've ever had. This review summarizes existing hypotheses on the mechanism of action (MOA) of memantine in an attempt to understand how the accepted interaction with NMDA receptors could allow memantine to provide both neuroprotection and reverse deficits in … I smoke tobacco bongs regularly so I seek out heavy nicotine rushes, but when on Memantine most of the rush is gone and it turns into a more deliriant-like experience. However, the drug does not cure Alzheimer’s. Take one dose every day, at the same time of day each day. The biggest turn off I see people have with recreational use of Memantine is it's duration, and while not overly exaggerated it is manageable. The one time I've combined LSD and a recreational dose of Memantine was one of the single most euphoric experiences I've ever had. Namenda (memantine): “My PCP put me on Namenda to supplement my Aricept for Alzheimer's Disease . Great write up, thanks for the info! Memantine is a medication used to treat moderate-to-severe Alzheimer's disease. How much does it help? To me I'd describe it as similar physical euphoria to a high 2nd plateau/low 3rd plateau DXM, and similar emotional effects, but without the mindfuck that DXM can cause. Memantine is substituted with a methyl carbon at both R3 and R5; it contains an amine substitution at R1. The review covers memantine studies in postherpetic neuralgia, diabetic pain, postoperative pain, complex regional pain syndrome, chronic phantom limb pain, opioid‐refractory pain and fibromyalgia. Hey guys, some of you may recognise me as that guy who goes on and on about Memantine's recreational value whenever given the chance, but up until now I didn't really have a way to explain how one might approach Memantine if they were interested in it's recreational potential. Its name is derived from its structure; 3,5-dimethyladamantan-1-amine. In addition, alcohol, opiates, stimulants and other dissociatives should be avoided when on recreational doses of Memantine as unwanted side effects, such as increased heart rates, respiratory depression, nausea and in worst case death, may occur. However, due to ketamine's difficultly to find, expense, and potential damage to the bladder, it isn't something I can regularly use. It still needs a little tidying up which i will get to over the next couple of days but i just wanted to say thank you. With the CAGR of X.X%, this market is estimated to reach USD XX million in 2026. Common side effects … I can't explain much further, simply because I can't remember what happens when I do it. 43% of those users who reviewed Memantine reported a positive effect, while 41% reported a negative effect. Once this is tidied up a little i will make it a featured article on the mainpage and post it to our facebook group. 279, 280 Via inhibition of NMDA receptors, memantine prevents the mitochondrial swelling, increases oxidative stress, and decreases … And personally I enjoy it a lot. Memantine Dosage. I don't think it's for everyone, but it certainly has enough merit for those who like dissociatives to try. the headspace has much less "static" noise, even compared to being sober. Also known as: Namenda, Namenda XR Memantine has an average rating of 5.3 out of 10 from a total of 55 ratings on Drugs.com. The peak is reached about 2-3 hours after ingestion and will plateau for another 10 hours before slowly diminishing. Over the years many people have toyed with it hoping to use it to abuse recreational drugs and not develop tolerance, this backfired obviously. The best part of Memantine is that it's available on the clearnet, although you'll have to find sources yourselves. Seeing as Erowid has limited information on Memantine this guide aims to add another resource out there. This is a risk reduction resource. 30mg seems to be barely a threshold dose. Get your prescription refilled before you run out of medicine completely. Mild potentiaition occurs but otherwise I haven't found a way to describe exactly what changes, it is a fairly unique experience. Whereas on DXM, it might be too hard to try to play a game. Memantine is great. A sub for discussing all uses of Memantine, from therapeutic to recreational. Although I cannot back up this claim with empirical evidence, Memantine is potentiated by Cannabis. Although there is moderate-certainty evidence that fewer people taking memantine experience agitation as an adverse event: RR 0.81 (95% CI 0.66 to 0.99) (25 fewer people per 1000, 95% CI 1 to 44 fewer), there is also moderate-certainty evidence, from three additional studies, suggesting that memantine is not beneficial as a treatment for agitation (e.g. I could see some thereputic use in this because of it's functionality and long half life. The mean age of patients who were receiving memantine and placebo was about 34.7 ± 4.48 and 31.5 ± 7.4 years, respectively. Although I cannot back up this claim with empirical evidence, Memantine is potentiated by Cannabis. From my personal experience, however, there is little chance of mania or anxiety even in high doses especially in comparison to DXM, and throughout the entire trip you will have a sense of contentment unwavering. Functional enough to play games like Overwatch and keep up with it without any struggle. Is it possible to hole on? I haven't pushed the limits enough to definitively say it exists. In high doses I found memantine to be a somewhat generic dissociative although it did have some psychedelic style visuals which was a little unusual. Memantine is a cough suppressant as well, so take note of how big your bongs are packed because you wont notice how big it is while pulling it. Memantine isn't very long term memory impairing, in comparison to DXM, or even Ketamine, but short term memory does seem to suffer a bit and you can lose trains of thought quite easily at high doses. Then memantine is pulled into the channel to its binding site. It's worth noting I have never experienced nausea from Memantine, possibly due to the 5-HT3 antagonism. Store memantine at room temperature away from moisture and heat. Its core structure is adamantane, a diamondoid of four interlocked cyclohexane rings in a stable 3-dimensional lattice conformation. Make sure you follow the RULES. With that being said, I don't think memantine would be an enjoyable experience for everyone. Memantine is used for treatment of moderate-to-severe stage of AD. I'll explain how some of these play a role in the subjective experience down further. Memantine is an uncompetitive NMDA receptor antagonist, and subjectively feels somewhere between Ketamine & DXM (perhaps closer to one of PCP analogues, but I can't comment on their subjective effects) with a longer duration than either. Results: From 2010 to November 2019, 307 topics citing memantine were identified on reddit.com and 136 users experiences extracted from the topics were recorded. Pharms - Memantine (309), Sleep Deprivation (140) : General (1), First Times (2), Hangover / Days After (46), Multi-Day Experience (13), Various (28) COPYRIGHTS: All reports are copyright Erowid and you agree not to download or analyze the report data without … Keep the liquid medicine bottle tightly closed with the cap provided. Above 100mg and you'll likely not be moving from your bed/couch very often, although it is possible. Ketamine: Much less sedating. Although heavy doses are still somewhat forgiving, in my experience, I wouldn't start with anything higher than 100mg, even with dissociative tolerance, purely based on duration. The Memantine market has witnessed growth from USD XX million to USD XX million from 2014 to 2019. 278 Memantine blocks the extensive activity of NMDA receptors but does not accumulate to interfere with normal synaptic transmission, and hence no disruption of normal physiological activity. Memantine seems less debilitating than that of Ketamine or DXM. I'm super happy I'm not the only one around here using it like this. You need to leave yourself at least 12 hours before you want to sleep before dosing. I feel very clear-headed on memantine. Nice trip report. I'm clumsy and stumbling a bit, but I'm able to use a keyboard and phone just fine. You will be given a small dose when you first start treatment. The high is quite non-intrusive though so it's really best used for a background high I think. Thanks again dude. Memantine is a moderate affinity, uncompetitive NMDA receptor antagonist with strong voltage-dependency and fast kinetics. Please comment back on what your experience was like at that dose though. Memantine seems to work in 'waves' similar to that of LSD, although intervals are somewhat shorter between swells. Some gastro-intestinal disturbances could be possible however, due to D2 agonism, there's not much info on this. Additional information on Memantine can be found: https://psychonautwiki.org/wiki/Memantine, https://www.erowid.org/pharms/memantine/memantine.shtml, Edit: If you've found this post recently, I've made a follow up post, answering some of the frequently asked questions I was receiving after making this post HERE. Due to its antagonism of the N-methyl-d-aspartate (NMDA) receptor, which has been shown to block rewarding and reinforcing effects of morphine, memantine has been investigated for potential utilization in … It feels almost like you can will yourself in and out of consciousness at that dose. Treatment should only be continued if beneficial effects are seen. Memantine was not effective at reducing cognitive deficits, and patients who tried memantine had more adverse effects such as fatigue . Do you have any previous experience with dissociatives, and if so how do they compare? It has a pretty clear anxiolytic effect on me. I have used ketamine in the past with the intention of helping depression and it was very pleasant at the time. Memantine 20 mg compared to placebo for mild AD (MMSE 20‐23) observed case (OC) ‐ six‐month studies for dementia. There are over-the-counter medications available to acidify the urine too; for example, pills containing methionine, which is used to prevent bladder infections.' If you're aiming for a “K-hole” like experience, then I would not recommend Memantine, its difficult to achieve, if at all possible, and if it were, the duration of it would be far beyond reasonable. Euphoria is more and more present, but loss of fine and gross motor control becomes more apparent. Your doctor will need to check your progress while you are using memantine. The site may not work properly if you don't, If you do not update your browser, we suggest you visit, Press J to jump to the feed. This includes: URLs, markets, PMs, etc. It is a long acting NMDA receptor antagonist that binds to an open channel binding site. How long do the effects last? Well dang, I'll have to figure out what my dose would be like (considering I have a dissociative tolerance currently). Depth perception is by far the biggest impacted sense, and in low light settings will make the room you're in feel like its constantly moving between being a cathedral in size to a shoebox. 2019 One meta-analysis showed that there was a significant improvement in cognitive function in AD patients who took memantine. In 2003, the FDA approved Memantine for the treatment of both severe and moderate Alzheimer’s disease. Low light settings let the visuals take hold much better and in complete darkness even 100mg may produce visuals on par with high Ketamine doses (for me high constitutes 200mg+), in a respective setting. I'd figured they would've found cough medicines that work just as well w/o being psychoactive during the War on Drugs but nah lol. As many comparisons to other common compounds as possible would be extremely useful for fleshing out the subjective effects section. Memantine seems to work in 'waves' similar to that of LSD, although intervals are somewhat shorter between swells. Adding the Alzheimer drug memantine to a selective serotonin reuptake inhibitor (SSRI) may improve depressive symptoms, as well as apathy, anxiety, and cognitive function, in older patients. However my memory lapses happen every 2 weeks or so and only for a short period. Don't dismiss it based on the lack of information that exists on here and elsewhere currently on the internet. A recent meta-analysis found substantial benefits of memantine in treating obsessive-compulsive disorder. TL;DR: Memantine has a high potential for recreational use. From experience, sublingual seems to have the fastest onset, and reasonable bioavailability, but the taste is rather unpleasant. Sorry, this post was deleted by the person who originally posted it. Memantine changed my life, therapeutic use fixed my depression, stopped me from compulsively using Ketamine to treat it, and has given me a quality of life I had only dreamed of, and I get to trip on it once in a while too. Memantine is on my bucket list, I really hope I get the chance to try it someday. Tobacco (most likely the nicotine, but I haven't ingested pure nicotine) also changes the subjective experience of Memantine, although only briefly. I tried memantine a few times and enjoyed it enough, but it’s a weird one, isn’t it? Ive had minimal unwanted physical side effects. Preface. 85mg Memantine Trip Report from January 2019 (edited, repost) Experience Report. It's clean feeling, compared to DXM. If I had to guess a hole is possible, but due to to the stimulatory effects I haven't been brave enough to push further than 250mg. OK just ingested 30 mg, we'll see, I don't want a full blown recreational high but I guess 30mg is good because many drugs just get my anxiety worse. Memantine also is a Dopamine D2 agonist, a non-competitive Serotonin 5-HT3 antagonist, a non-competitive nAChRs antagonist with similar potencies to NMDA antagonism and the Sigma σ1 receptor with potentially negligible activity. If it isn't apparent guys, I have a lot of spare time. A short intro to Memantine. But if you like dissociatives like DXM/Ketamine, I think it's definitely worth trying. Use memantine regularly to get the most benefit. It was first developed in the 1960s for the treatment of diabetes. Sweet write up, it sounds like an interesting drug worth experiencing. Never heard of this drug before. 3 McShane R, Westby MJ, Roberts E, Minakaran N, Schneider L, Farrimond LE, Maayan N, Ware J, Debarros J. Memantine as a treatment for dementia, Dementia and Cognitive Improvement Group. Nice report. Can you elaborate more on how it helped your depression? It is taken by mouth. Deprescribing ChEIs and memantine through shared decision making with individuals and their caregivers by: determining their treatment goals; discussing benefits and harms of continuing and ceasing medication, from the start of therapy and throughout; and engaging them in monitoring after discontinuation, while informing carers that the individual will continue to decline after discontinuation. Memantine helps to ease the symptoms of dementia in Alzheimer's disease. ... T+03:00 Texted my friend for a bit, browsed Reddit, watched YouTube. It is less preferred than acetylcholinesterase inhibitors such as donepezil. (Yes, citric acid causes your urine to become more alkaline, I learnt the hard way) A single oral dose is highly recommended. Continuous outcomes. Could you describe to me in as much detail as possible how it feels in comparison to traditional dissociatives such as ketamine, mxe and dxm? Memantine is a prescription drug that is also known by the brand name Namenda. New comments cannot be posted and votes cannot be cast. The physical euphoria is apparent, dissociation is only mild, and its still quite easy to stay focused and motivated. Visually fairly similar to ketamine, but more controllable. Results were inconclusive because of studies with poor levels of … Memantine for dementia – what, why, who and when? Not using is always safer. The new dementia NICE guidelines published in June 2018 state that we should consider memantine for patients with moderate Alzheimer’s Disease and offer memantine for people with severe Alzheimer’s Disease, and if the person is already I’d recommend slowly exploring higher doses, some of my heroic doses on Memantine have given me experiences I haven’t had on any other drug, and I’ve IM’d 300mg+ ketamine and taken doses as high as 125mg DCK, (on separate occasions) and they still haven’t touched the headspace I’ve reached on Memantine. Good, comprehensive guide/advice. Less introspective. The visuals and euphoria become much more intense and interesting after weed is smoked. Memantine acts as a mild stimulant, raising heart rate and with a sense of weightlessness it feels encouraging to be physically active at low doses. That way, memantine is eliminated 7-10 times faster. The physical euphoria is almost like a soft buzzing, underneath the skin, most noticably in the hands, toungue, scalp, and behind the legs. Memantine is commonly used for the treatment of moderate-to-severe Alzheimer's disease. Press J to jump to the feed. I want to bring it to light as the amazing drug it is. How often do you use Memantine for depression? I have a few questions regarding its effects however. One interesting memantine side effect includes higher libido. Don't re-dose thinking it wasn't a high enough dose, you'll regret the compounding effects of multiple doses. You can drink cranberry juice to acidify your urine throughout your trip to shorten it's duration, avoid citrus and other foods that basify your urine. If you over shoot it, it's a very long time to endure it. The results have shown a significant difference in the behavior and attention deficit between the two groups treated with memantine and placebo during 6 weeks (p < 0.001). What is it with cough suppressants getting us high as shit? Seems to help my short term memory. And anything else you might like to add. When it is working I can think clearly. Thanks! Onset is between 45-180 minutes (As short as 30 minutes sublingually, from experience), so you'll be sitting around for a bit waiting for it to kick in. Press question mark to learn the rest of the keyboard shortcuts. It's euphoric, mildly stimulating, and very clear headed compared to other dissociatives. For those who want to use memantine for treating … This means that for memantine to bind, the neuron has to depolarize, and open to clear the magnesium block. I've never seen a new user format an article so legitimiately in accordance with the rest of the site. Memantine, or 3,5-dimethyladamantan-1-amine, is a man-made molecule classified as a substituted adamantane derivative. New comments cannot be posted and votes cannot be cast, More posts from the MemantineHCl community. Dosing Memantine is simple, but requires some planning and forethought. Just remember that there is no 100% safe drug use. And for the most part I'm perfectly functional cognivitely. In this study, we evaluated whether a combination of memantine with melatonin, administered for 32 days in drinking water, was more effective than either drug alone with respect to Aβ aggregates, neuroinflammation and cognition in the double transgenic APP/PS1 (5xFAD) mouse model of AD. That being said, Memantine is a beautiful drug. 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